association of atp-binding cassette transporter a1 (<i>abca1</i>)-565 c/t gene polymorphism with hypoalphalipoproteinemia and serum lipids, il-6 and crp levels
نویسندگان
چکیده
background: atp-binding cassette transporter a1 (abca1) is a membrane integral protein which plays a vital role in high density lipoprotein (hdl) metabolism and exerts a protective effect against hypoalphalipoproteinemia (ha) by mediation of rate-limiting step in hdl biogenesis. in addition, this protein possesses anti-inflammatory effects by inhibiting the production of some inflammatory cytokines in macrophages. this study investigated the association of abca1-565 c/t gene polymorphism with ha and serum lipids, il-6 and crp levels. methods: a population which consisted of 101 ha and 95 normal subjects were genotyped for abca1-565c/t polymorphism by polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp). the serum concentrations of lipids, il-6 and high sensitive-crp (hs-crp) were measured by the relevant methods. results: the frequency of t allele was significantly higher in the ha group than the controls (31.7 vs. 19.5%, p=0.002). thus, carriers of the t allele (ct and tt genotypes) had a higher risk for ha (p=0.016, or=2.04, 95% ci=1.14-3.63). t allele carriers demonstrated decreased hdl-c and increased triglyceride, il-6 and crp levels than those with the cc genotype. conclusion: this study suggests that the-565 c/t polymorphism of abca1 gene is associated with an increased risk of ha, decreased hdl-c and increased tg, il-6 and crp.
منابع مشابه
Association of ATP-Binding Cassette Transporter A1 (ABCA1)-565 C/T Gene Polymorphism with Hypoalphalipoproteinemia and Serum Lipids, IL-6 and CRP Levels
BACKGROUND ATP-binding cassette transporter A1 (ABCA1) is a membrane integral protein which plays a vital role in High Density Lipoprotein (HDL) metabolism and exerts a protective effect against Hypoalphalipoproteinemia (HA) by mediation of rate-limiting step in HDL biogenesis. In addition, this protein possesses anti-inflammatory effects by inhibiting the production of some inflammatory cytoki...
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عنوان ژورنال:
avicenna journal of medical biotechnologyجلد ۹، شماره ۱، صفحات ۳۸-۴۳
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